Hybrid DNA Aptamers

and Assessment of G-Quadruplex Stability by Temperature Ramp Experiments

A Chirascan case study.

Zavyalova Et Al

This study compared stabilities of different  thrombin DNA aptamers that were modularly constructed as G-Quadruplex / Duplex hybrids.

Both the quadruplex topology (parallel or anti-parallel) and the thermal stability was dependent on the duplex modules.

See the original paper here:

Zavyalova et al. 2019, Biomol. 9:41

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Have a look at the system that was used in this study.

Chirascan VX
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