Chirascan VX

The laboratory standard circular dichroism instrument

Suitable for studying chiral molecules of all types and sizes, this Chirascan CD spectrometer has featured in thousands of publications since its introduction in 2005. Often used to analyze biomolecules, Chirascan data contributes to a deeper understanding of biomolecular characteristics, mechanisms and interactions.

More than α-helix and β sheet -
determine structural and thermodynamic properties

Gain insight and detect changes in secondary and tertiary structure
Determine response to thermal or chemical change
Study folding and unfolding mechanisms
Expand capabilities with dedicated

Chirascan accessories

Publications

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Features and accessories

Chirascan systems are supplied with the features and accessories required for acquisition of high quality data from ‘day one’.

Molecular sieve, activated charcoal filter

Removes common gas impurities

Active nitrogen management system

Regulates purge gas consumption
Software-controlled

Air-cooled xenon lamp

Software-controlled
Up-time recorded

Monochromator

Produces horizontally, linearly polarized monochromatic light
Dual polarizing prisms maximize light throughput

Photoelastic modulator

Converts horizontally polarized light to circularly polarized light. Alternates between left- and right-handed circular polarized light

Temperature-controlled sample chamber

Consistent analytical conditions
Continuous temperature ramps (single sample mode)

Water circulator

Dissipates heat from sample chamber and sample storage Peltiers

Cuvettes and holders

Selected for far- and near-UV CD analysis of biomolecules (single sample mode)

Photomultiplier Detector

Control and analysis software

Easily defined run parameters and store routine protocols
Saves time with scheduled start-up/shutdown of lamp and N₂ supply
Fail-safe lamp switch-off if N2 flow drops
Ensures O₂-free conditions with N₂ purge
Recognizes flow cell to select optimal run/wash/dry protocol

Customer Experiences

Dr Dan Pantos

Dr Dan Pantos, a Senior Lecturer and Head of Organic Chemistry at the University of Bath, utilises the Chirascan CD instrument from Applied Photophysics for various research projects. His primary research involves studying the interactions between chiral small molecules and quadruplex DNA, with the goal of developing anti-cancer treatments.

Dr Tonya Zeczycki

Dr Tonya Zeczycki, an associate professor at the Brody School of Medicine at ECU, studies Alzheimer's, Parkinson's, and other neurodegenerative diseases in her lab. She focuses on protein interactions, misfolding, and aggregation.

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